Changes in the triglyceride metabolism in the thigh muscle and liver of broilers injected intravenously with angiopoietin-like protein 4

Angiopoietin-like protein 4 (ANGPTL4) is a potential circulating mediator connecting nutritional factors and fat metabolism, however, information lacking on the exact role of ANGPTL4 triglyceride metabolism in thigh muscles livers broilers. The objective this study was to determine changes broilers injected intravenously with ANGPTL4. In experiment 1, 36 male Arbor Acres at 35 days age were randomly allocated into six treatments replicates. subjected intravenous injection polyhistidine-small ubiquitin-related modifier-ANGPTL4 (His-SUMO-ANGPTL4) once dose 0, 20, 100, 500, 2 or 12 500 ng/kg body weight (BW), respectively. results showed that His-SUMO-ANGPTL4 BW decreased (P < 0.05) broilers' heart-fatty acid-binding (H-FABP) mRNA expression muscle. All broiler groups had lower adipocyte-fatty 2, 18 three given an normal saline (NS), His-SUMO, (500 BW) once. receiving H-FABP Besides, increased fatty acid synthase activity microsomal transfer liver. However, concentrations high-density lipoprotein, low-density very insulin, growth hormone leptin serum not affected by injection. conclusion, has ability change